Uvivinyo olusha lwezempilo selulethe ubufakazi obuqinisekisa ukuthi ukudla nsuku zonke kwamaphilisi e-collagen yenkomo kungathuthukisa kakhulu izimpawu ezibalulekile zezempilo yesikhumba. Ucwaningo oluyimpumputhe kabili, olulawulwa yi-placebo, olwashicilelwa ku-Cosmetics 2025, lwathola ukuthi abesifazane abasebenzise amagremu angu-2.5 we-collagen peptide yenkomo ethile nsuku zonke izinyanga ezishiyagalombili bahlangabezana nokwanda okungu-26% ekugcinweni kwamanzi esikhunjeni, ukuncipha okungu-25% kwevolumu yemibimbi, nokuthuthuka okungu-9% ekugudumeni kwesikhumba. Lezi zitholakele zibeka i-collagen peptide yenkomo njengesithako esinamandla emkhakheni wobuhle nempilo, enikeza izinzuzo ezilinganisekayo ezilwa nalezo zezinye izinto ezivela olwandle. Ezinkampanini ezihlola ukutholwa kwezithako, le mibiko igcizelela ukubaluleka kwe-bioactivity ye-peptide kanye nekhwalithi yokwakheka ngaphezu komthombo wesilwane kuphela. I-Jilin Senwell Biotech Co., Ltd., umphakeli omethembayo emhlabeni wonke wezithako zezitshalo nezilwane ezisezingeni eliphezulu, iyakubona ukufunwa okukhulayo kwezithako ze-collagen ezisebenza kakhulu futhi izibophezele ekuhlinzekeni izinto zokusetshenziswa eziphephile, eziphumelelayo kubakhiqizi emhlabeni wonke. Lesi sihloko sihlaziya indlela ucwaningo olwenziwa ngayo, imiphumela, izindlela, kanye nemiphumela yezentengiselwano, sinikeza umthombo obanzi ochwephesheshe bemboni abafuna ukuqonda amandla aphelele e-collagen peptide yenkomo.

Ucwaningo lwezempilo luhlolisise i-peptide ye-collagen yenkomo efana ne-Verisol B formulation eyaziwayo. Ababambiqhaza banikezwa umthamo wansuku zonke wama-gram angu-2.5 isikhathi samaviki ayisishiyagalombili, nezinga elithathwe ekuqaleni, emavikini amane, nasevikini ezimbili. Umphumela obaluleke kakhulu kwaba ukwanda okungu-26% ekugcinweni kwamanzi esikhunjeni ngemuva kwamaviki ayisishiyagalombili wokudla, nokuthuthuka okubonakalayo okungu-18% okwabonakala kakade emavikini amane. Lokhu kuqala okusheshayo kwezinzuzo zokugcinwa kwamanzi kubonisa ukuthi i-peptide ye-collagen yenkomo isebenza kumathambo esikhumba ngokushesha, okwenza kube yindlela ekhangayo kubathuthukisi bemikhiqizo abahloswe ukuletha imiphumela ebonakalayo kubathengi. Ngaphezu kokugcinwa kwamanzi, ivolumu yemibimbi yehle ngo-25% esikhathini sonke socwaningo, kuyilapho ubuqotho besikhumba buthuthuke ngo-9%. Lezi zilinganiso ezintathu - ukugcinwa kwamanzi, ukuncishiswa kwemibimbi, nobuqotho - ziphakathi kwezinhloso ezifunwa kakhulu embonini yezokulwa nokuguga nokunakekelwa kwesikhumba, futhi idatha ibonisa ukuthi i-peptide ye-collagen yenkomo ingaletha kuzo zonke izinhlangothi ngasikhathi sinye. Kubathuthukisi, le miphumela ihlinzeka ngesisekelo esiqinile sesayensi sokubeka imikhiqizo equkethe impuphu ye-collagen yenkomo eyenziwe ngama-hydrolyzed njengezixazululo ezinobufakazi besayensi ekugugeni kwesikhumba nokoma.

Ubukhulu balezi ngcono bubaluleke kakhulu uma buqhathaniswa nezinye izindlela zokudla zezempilo yesikhumba. Izithako eziningi zomlomo zidinga izinyanga eziyisithupha noma ngaphezulu ukuze zibonise izinguquko ezibonakalayo, kodwa-ke lesi sifundo sezinyanga ezisishiyagalombili sinikeze imiphumela ebalulekile ngokwezibalo. Iqembu le-placebo, njengoba kulindelekile, libonise izinguquko ezincane kuyo yonke imingcele eyalinganisiwe, liqinisekisa ukuthi imiphumela ebonakalayo ibangelwa ngqo ukungenelela kwe-bovine collagen peptide. Ngaphezu kwalokho, ukungaguquguquki kokuphucuka kuyo yonke imingcele eminingi kubonisa ukuthi iphrofayili ye-peptide yalesi sithako esithile ivuselela ukuvuselelwa okuphelele kwesikhumba kunokugxila esimpawini eyodwa. Amabhizinisi ahlola izinketho zezithako zomugqa wabo omusha womkhiqizo kufanele acabange ukuthi ama-peptide e-bovine collagen anikwa utshani, uma ehlanjululwe kahle futhi enomsebenzi, angase anikeze ukusebenza okufanayo kwezomtholampilo. Idatha evela kulesi sifundo ingasetshenziswa ngokuzethemba ezimangweni zokumaketha, inqobo nje uma izincazelo ze-peptide kanye nenqubo yomthamo zifana.

Ukuze siqonde ukuthi kungani i-bovine collagen peptide ikhiqiza imiphumela eqinile kangaka, kubalulekile ukuhlola ubufakazi be-in vitro obusekela indlela yayo yokusebenza. Izifundo zaselebhu ezisebenzisa ama-human dermal fibroblasts zibonise ukuthi ama-collagen peptides athile asebenzayo akhuthaza ukwenziwa kwe-type I collagen, i-elastin, nama-proteoglycans — izinto ezintathu eziyinhloko ze-extracellular matrix ezinikeza isikhumba sakho isakhiwo, ukuqina, namandla okugcina amanzi. Lokhu akuyona nje indaba yokuhlinzeka ngama-amino acids aluhlaza; kunalokho, iziqephu zamaphethelo ezihlukile ezikhona ku-hydrolyzed bovine collagen powder zisebenza njengezimpawu zokuxhumana ezicela ama-fibroblasts ukuthi andise ukukhiqizwa kwawo kwamaprotheni we-matrix. Le nqubo ihlanganisa ukuvuselelwa kwezindlela zokubonisa izakhi zofuzo, okuhlanganisa nalezo ze-collagen type I alpha 1 ne-elastin, okuholela ekwanda okulinganisekayo ekubekeni amaprotheni esikhunjeni. Le ndlela yebhayoloji ichaza ukuthi kungani ukuthuthuka kokugcinwa kwamanzi esikhunjeni nokuqina okubonwe esivivinyweni sezokwelapha kwagcinwa futhi kwaqhubeka esikhathini samaviki ayisishiyagalombili.

Esinye isici esibalulekile somshikashika yikhono le-bovine collagen peptide lokumelana nokugayeka ngokuphelele emgudwini wokugaya. Ingxenye yamapetide edliwayo iyasinda ekwephulweni kwamajusi e-enzymatic futhi iyimuncwa egazini ngendlela yamapetide amabili namathathu, njenge-prolyl-hydroxyproline ne-hydroxypropy-glycine. Lawa mapetide amancane bese aqongeka esikhunjeni ngemishikashika ethile yokuthutha, lapho enza khona imiphumela yawo ye-bioactive ngqo kuma-fibroblasts esikhumba. Ngaphezu kwalokho, amanye amapetide we-collagen abonisa izakhiwo ze-antioxidant, ezisusa ama-free radicals angadala ukubola kwe-collagen ne-elastin fibers ezikhona. Lesi senzo esiphindwe kabili — ukukhuthaza ukwenziwa kwe-matrix entsha ngenkathi kuvikelwa izakhiwo ezikhona — kwenza i-bovine collagen peptide ibe yisithako esisebenza kahle kakhulu ezinhlelweni zokulwa nokuguga. Ezinkampanini ezithola i-bovine hide collagen peptides, ukuqinisekisa ukuthi inqubo yokukhiqiza igcina lezi ziqephu ze-bioactive kubalulekile ukuphinda imiphumela yezokwelapha ebonwe ocwaningweni olushicilelwe. I-Jilin Senwell Biotech Co., Ltd. igcizelela ukulawulwa kwekhwalithi okuqinile kuyo yonke imigudu yayo yokuhlinzeka ukuze kugcinwe ubuqotho be-peptide kanye ne-bioactivity.

I-Collagen iyiproteni eningi kakhulu emzimbeni womuntu futhi iyisisekelo esiyinhloko sokwakha isikhumba, amathambo, imisipha, imisipha, nemithambo yegazi. Kunezinhlobo eziningi kakhulu ezaziwayo ze-collagen, kodwa izinhlobo I, II, kanye ne-III zenza iningi elikhulu le-collagen yomzimba wonke. Uhlobo lwe-collagen I lunikeza amandla esikhumba, amathambo, nemisipha; uhlobo lwe-II lutholakala kakhulu ku-cartilage futhi lusekela impilo yamalunga; futhi i-collagen yohlobo lwe-III iqhakambisa ubuqotho bezicubu futhi ivame ukutholakala eduze nohlobo lwe-I esikhunjeni nasemithanjeni yegazi. I-collagen yenkomo ingacebile ngokwemvelo kuzo zombili izinhlobo ze-collagen I kanye ne-III, okwenza ilungele kakhulu izicelo ezihlosiwe ezimpilweni zesikhumba, ukuphulukiswa kwamanxeba, kanye nokusekelwa kwezicubu ezixhumanisa. Ngokuphambene, i-collagen yasolwandle ingeyohlobo lwe-I ikakhulu, kanti i-collagen yenkukhu ingacebile kuhlobo lwe-II. Ngakho-ke, ukukhethwa komthombo kufanele kuhambisane nomphumela wezempilo ohlosekayo, futhi emikhiqizweni egxile esikhunjeni, i-bovine collagen peptide inikeza iphrofayili efanele yezinhlobo ze-I kanye ne-III.

Ukutholakala kwe-collagen emzimbeni kuncike kumaphesheya ethile we-peptide akhiqizwa ngesikhathi sokuhlanjululwa, kunokuba kuncike ohlotsheni lwesilwane kuphela. I-peptide ye-collagen yenkomo eyenziwe kahle enengxenye ephezulu yamaphesheya anesisindo esiphansi (ngokuvamile ngaphansi kuka-3 kDa) ingafinyelela amazinga okumunca afana noma adlule awezinsiza zasolwandle. Lokhu kuyinto ebalulekile kubakhiqizi abangase bacabange izindleko nokusimama kwezinto ezahlukene zokusetshenziswa. Impushana ye-collagen yenkomo edliwe utshani, ikakhulukazi, ihlangabezana nezidingo zabathengi abafuna izithako ezihlanzekile futhi ezitholwe ngokuziphatha, futhi izifundo zakamuva ziqinisekisa ukuthi ukusebenza kwayo kwezomtholampilo kuyafana nokwe-collagen yasolwandle lapho iphesheya ye-peptide ilungiswa kahle. Ngaphezu kwalokho, i-collagen yenkomo inokunambitheka okungathathi hlangothi nokuncibilika okuhle, okwenza kube lula ukuyifaka kuziphuzo, ama-gummies, izimpushana, nokudla okusebenzayo ngaphandle kokudicilela phansi ikhwalithi yokuzwa. Ezinkampanini ezifuna ukuhlukanisa izinhlobonhlobo zemikhiqizo yazo, impushana ye-collagen yenkomo eyenziwe yahlanzwa inikeza ukuguquguquka, ukusebenza, kanye nokukhanga okunamandla kwabathengi, ikakhulukazi lapho isekelwa imininingwane yezomtholampilo njengaleyo evela ocwaningweni lwe-Cosmetics luka-2025.

Ucwaningo lwenzelwe njengesilingo esiyimfihlo kabili, esilawulwa yi-placebo esihlehlisiwe, okuyinto eyigugu ocwaningweni lwezokwelapha ekudleni kanye nesikhumba. Abesifazane abangu-66 abaneminyaka ephakathi kuka-35 no-55 ubudala babhaliswa, ubudala obubamba isikhathi lapho ukukhiqizwa kwe-collagen yemvelo kuqala ukwehla kakhulu futhi ukuguga kwesikhumba kubonakale kakhulu. Abahlanganyeli bahlelwa ngokungahleliwe ukuthi bathole amagremu angu-2.5 ngosuku we-bovine collagen peptide noma i-placebo, futhi abacwaningi nabahlanganyeli babengazi ukuthi bangabaphi kuze kube yilapho ucwaningo luvulwa. Izilinganiso zathathwa ngezikhathi ezintathu: isisekelo (ngaphambi kokuba kuqale ukwengezwa), isonto lesine, nesonto lesishiyagalombili. Izimpawu eziyinhloko kwakuyisikhumba esimanzi, ivolumu yezibazi ezungeze amehlo (indawo ejwayelekile yokulimala okubangelwa ukukhanya nokuguga kweminyaka), kanye nokuvumelana kwesikhumba. Zonke izilinganiso zenziwa kusetshenziswa izindlela ezisemthethweni eziqinisekisiwe - i-corneometry yokumanzi, i-pringlometry yevolumu yezibazi, kanye ne-cutometry yokuvumelana - ukuqinisekisa idatha engoqobo futhi ephindeka kalula.

Ukwakhethwa komthamo wansuku zonke wama-2.5-gram kubaluleke kakhulu ngokwelashwa ngoba uphansi uma uqhathaniswa nemikhiqizo eminingi yekholajeni ethengiswayo encoma amagremu angu-5 kuya ku-10 ngosuku. Lokhu kubonisa ukuthi iphrofayili ethile ye-peptide esebenza ngokwezinto zokwelapha yekholajeni yenkomo eyahloliwe ivumela umthamo ophansi osebenzayo, onganciphisa izindleko zokwakheka futhi uthuthukise ukuthobela kwabathengi. Isikhathi sokufunda samaviki ayisishiyagalombili naso siyasebenza ezinyathelweni zokuthuthukisa umkhiqizo, njengoba sihambisana nezikhathi ezijwayelekile zokuqinisekisa izimangalo zokwelashwa. Bonke ababambiqhaza bayalelwa ukuthi bagcine ukudla kwabo okuvamile kanye nezinqubo zokunakekela isikhumba sabo kulo lonke uvivinyo ukuze kuqhakamshelwe umphumela wezithako. Ukuhlaziywa kwezibalo kubonise umehluko omkhulu kakhulu phakathi kwamaqembu ekholajeni ne-placebo ngamaphuzu esikhathi samaviki amane nawamaviki ayisishiyagalombili, ngobukhulu bomphumela obukhulu ngokwanele ukuba bubaluleke ngokwelashwa. Kubakhiqizi, amandla ale ndlela yokwakheka yocwaningo ahlinzeka ngobufakazi obuqinisekile obungacashunwa ekuhanjisweni kwemibhalo yokulawula, izinto zokumaketha, kanye nezokuxhumana kochwepheshe, ikakhulukazi lapho uthola izithako kubahlinzeki abathembekile abangafanisa imininingwane ye-peptide esetshenziswe ocwaningweni.

Umbhali oyinhloko ocwaningweni, uProksch nabalingani bakhe, bagcina ngokuthi ukusebenza kahle kwezempilo kokungezwa kwe-collagen akuncikile kakhulu ohlobo lwesilwane lapho i-collagen ivela khona. Kunalokho, izinto ezibalulekile yi-bioactivity yamaphrothi kanye nokwakheka okuphelele - okuhlanganisa nomthamo, ukusatshalaliswa kwesisindo samamolekyuli, kanye nokuba khona kwezithako ezisebenzisana njenge-vitamin C noma i-hyaluronic acid. Lesi siphetho siyishintsho esibalulekile ekucabangeni komkhakha ukuthi i-collagen yasolwandle ingcono kune-collagen yenkomo ezinhlelweni zokunakekela isikhumba. Eqinisweni, ukwanda okungu-26% kokunisela kanye nokuncipha okungu-25% kwevolumu yemibotshana okubonwe nge-collagen peptide yenkomo kulesi sifundo kuyafana nemiphumela emihle kakhulu ebikwe ezivivinyweni ze-collagen ezisekelwe olwandle. Okusho ukuthi kubathengi bezithako nabathuthukisi bemikhiqizo kucacile: i-collagen peptide yenkomo, ikakhulukazi uma itholakala njenge-collagen peptides yenkomo edliwe utshani enomlando we-peptide oqinisekisiwe, ingaba yindlela ephumelela kakhulu, engabizi kakhulu esikhundleni se-collagen yasolwandle ngaphandle kokudela imiphumela yezokwelapha.

Ezinkampanini ezifana neJilin Senwell Biotech Co., Ltd., lezi zitholakele ziqinisekisa inani lokunikeza izithako ze-collagen ezivela emhlambini ezihlangabezana namazinga aphezulu kakhulu. Le nkampani iqinisekisa ukuthi zonke izinto zokusetshenziswa ziphephile, ziyathembeka, futhi zitholakala emithonjeni ehlangabezana namazinga okuphepha kazwelonke, ihlinzeka abakhiqizi ngomnyombo wokuhlinzekwa oqhubekayo. Ngaphezu kwalokho, insizakalo yomphathi wezinga lokuqala yeSenwell isebenza izinsuku ezingu-365 ngonyaka, iyatholakala amahora angu-24 ngosuku ukuhlangabezana nazo zonke izidingo zamakhasimende ngokuzinikezela nobuchwepheshe — kusukela kusekelo lobuchwepheshe kuya kusizo lokwakheka ngokwezifiso. Njengoba isidingo sezithako ezisekelwa yisayensi, ezisimeme, futhi ezitholakala ngokuziphatha siqhubeka nokwanda, i-bovine collagen peptide ibekwe kahle ukuthola isabelo esikhulu semakethe engxenyeni yobuhle obuqhamuka ngaphakathi. Amabhizinisi atshala imali emfundweni mayelana nesayensi ye-peptide bioactivity futhi akhetha abahlinzeki ababeka phambili ikhwalithi bazobekwa kahle ukuze baqalise imikhiqizo ehambisana nabathengi abanolwazi abafuna imiphumela yangempela, eyalinganisekayo.

Ucwaningo lwanyatheliswa kuyi-journal i-Cosmetics 2025, Volume 12, Issue 2, Article 79, nge-DOI 10.3390/cosmetics12020079. Imininingwane egcwele yokucaphuna iyatholakala kubafundi abafisa ukuhlola idatha eluhlaza kanye nokuhlaziywa kwezibalo. Ochwephesheshe bemboni, leli phepha liyisengezo esibalulekile esisekelayo ku-collagen peptide yenkomo njengesithako esisemthethweni nesinamandla. Ukuze uhlale unolwazi ngocwaningo lwakamuva kanye nokusha kwemikhiqizo, vakashela i-Izindaba ikhasi kwaJilin Senwell Biotech, lapho izindaba zenkampani nezimboni — okubandakanya izitayela zemakethe nentuthuko yokumisa izindinganiso — ziphumelela njalo. Ngeminye imininingwane mayelana nohlu olugcwele lwezithako ezitholakalayo nezithako zokudla, hlola i-Imikhiqizo ikhathalogi, futhi ngemibuzo mayelana nokuthola izinto ngokwezifiso kanye nokwesekwa kwezobuchwepheshe, thintana nethimba nge-Ukusekelwa ikhasi noma uvakashele i-Mayelana Nathi ikhasi ukuze ufunde ngeminyaka engu-18 yesipiliyoni sikaSenwell kanye nokufinyelela kwakhe emhlabeni jikelele. I-Ikhaya ikhasi linikeza isibuyekezo esiphelele sezitifiketi zenkampani, imikhiqizo ethengiswa kakhulu, namandla enkampani kubalingani abasha abahlola amathuba okubambisana.